Liver Microphysiological Systems
Human-relevant liver models for predictive hepatotoxicity and metabolism studies
Choose from validated monoculture, triculture, or tetraculture configurations designed to match your research objectives and biological question.
Select the right liver model for your study
Model complexity should match your biological question and decision point. Each configuration provides validated, human-relevant data — select based on what cellular interactions you need to capture.
How to select the right liver model
Model complexity should match your biological question and decision point.
| Model | Select this model when you need to... | What this adds beyond simpler models |
|---|---|---|
| Liver Monoculture MPS | Establish baseline hepatocyte function, metabolic competence, and intrinsic hepatotoxicity | Provides primary human hepatocyte metabolic baseline for early screening and clearance profiling |
| Liver Triculture MPS | Understand how stromal and vascular cells modulate compound toxicity or metabolism | Stellate and endothelial cell crosstalk reveals vascular-mediated effects and extracellular matrix interactions |
| Liver Tetraculture MPS | Assess immune-mediated toxicity, inflammatory response, or long-term chronic exposure effects | Kupffer cells enable immune–hepatic crosstalk, cytokine profiling, and inflammation-driven injury mechanisms |
Use this model in your research
The Liver MPS platform supports different study types depending on your team's resources, expertise, and timeline. Choose the approach that fits your workflow.
Build Your Own
Design a Custom Multi-Organ System with NANOSTACKS™
The NANOSTACKS™ Multi-Organ Builder lets you select one or multiple organs — Liver, Lung, Heart, Brain, Gut, Kidney, Skin — and automatically configures your multi-organ system with the right cell layers, compartments, and 3D visualisation.
- ✓Select organs individually or build a multi-organ panel
- ✓Cell layers and compartments configured automatically
- ✓Interactive 3D model updates in real time
- ✓Download schematic and request a quote in one step
