Neurotoxicity Testing Services
Our neurotoxicity testing services combine advanced human brain models, MEA electrophysiology, and AI-driven analysis to deliver decision-ready neuronal safety insights.
Revivocell operates fully managed neurotoxicity studies from experimental design through data interpretation, using brain microphysiological systems that capture functional CNS risk beyond conventional viability and neurite assays.
Why Revivocell
Conventional neurotoxicity assays often fail to predict human neuronal safety due to limited cellular complexity, lack of functional readouts, and non-physiological culture conditions. Revivocell's brain microphysiological systems are designed to overcome these limitations by recreating key aspects of human brain biology in vitro.
Functional connectivity
Configuration-dependent MEA-based analysis capability
Enables detection of sub-lethal and network-level neurotoxicity not captured by conventional viability assays.
Real-time neuronal monitoring
Continuous activity tracking over weeks
Human-relevant neuronal networks
Multicellular neural models selected based on study objectives
Human-relevant readouts
Clinically translatable biomarkers
We run the study for you
Revivocell provides fully managed neurotoxicity studies, from experimental design through to data interpretation, using our brain microphysiological systems.
- Study design and protocol definition
- Compound dosing and experimental execution
- Quality control, data analysis, and reporting
Comprehensive neurotoxicity evaluation
Electrophysiological analysis
Biomarker profiling
Network activity assessment
How It Works
Introductory call
Discuss objectives and compounds
Study plan and quote
Receive detailed protocol and pricing
Experimental execution
By our scientific team
Report delivery
With data, QC, and interpretation
Who this service is for
Pharmaceutical and biotechnology companies
AI / machine-learning companies
CROs
Academic and translational research groups
Core Study Endpoints
Functional Neurotoxicity (Primary)
Microelectrode array (MEA) readouts
- Spike rate and burst frequency
- Network synchrony
- Neuronal firing patterns
Structural & Viability Endpoints (Supportive)
- ATP levels
- LDH release
- Live/dead imaging
- Axonal integrity
Advanced & AI-Ready Outputs
- Time-series electrophysiology
- High-content imaging
- Multiparametric feature extraction
What you receive from a Revivocell study
Comprehensive, decision-ready outputs delivered by our scientific team
Detailed study report
Full experimental protocol, raw data, statistical analysis, and quality control metrics
Quality control documentation
Neuronal viability, network function benchmarks, and assay performance indicators
Scientific interpretation
Expert analysis of neurotoxicity patterns, dose-response curves, and compound-specific findings
Decision-ready outputs
Clear conclusions and recommendations to support go/no-go decisions or regulatory submissions
Evidence-Based, Decision-Ready Data
Our neurotoxicity studies use brain microphysiological systems with demonstrated functional neuronal activity, giving you confidence in the biological relevance of your data.
Why our models deliver confident decisions
- Demonstrated response to known neurotoxicants
- Long-term neuronal network stability with functional activity
- Human-relevant electrophysiological patterns
- High-content multiparametric analysis for mechanistic insight
Application note validation
Our NANOSTACKS™-based brain models are supported by documented application notes demonstrating functional neuronal networks and neurotoxicity assessment capabilities.