Brain MPS Platform Overview
The Brain MPS is built on the modular NANOSTACKS™ platform, enabling physically separated, layered neural co-cultures under controlled in vitro conditions.
The platform supports multiple neural configurations and analytical workflows depending on the neurotoxicity question, cell source, and readout strategy.
Each layer represents a discrete, permeable cellular compartment.
Neurotoxicity Questions Addressed
Demonstrated Brain MPS Applications
Multicellular in vitro brain models enable more physiologically relevant assessment of neurotoxicity than traditional monocellular systems. The Brain MPS supports distinct neurotoxicity applications using different neural configurations and analytical readouts.
Structural Neurotoxicity & Neurite Outgrowth
Best suited for early hazard identification and structural neurotoxicity assessment.
Available Readouts
- Neurite outgrowth and branching
- Neuronal morphology
- Imaging-based cytotoxicity
- Dose- and time-dependent effects
Model Configuration
- • Astrocyte–neuron co-culture
- • Cell line–based neural systems (e.g. SH-SY5Y, astrocyte-like cells)
Concentration-dependent decrease in neurite outgrowth following compound exposure.
Functional Neurotoxicity & Seizure Liability
Best suited for functional CNS safety and seizure liability assessment.
Available Readouts
- Neuronal network activity
- Burst dynamics and synchrony
- Electrophysiological endpoints
- AI-ready functional datasets
Model Configuration
- • iPSC-derived human neurons and astrocytes
- • Optional microglia
- • MEA-compatible configuration
Brain MPS integrated with MEA technology for functional assessment of neural network activity.
Practical Details
- PlatformNANOSTACKS™ modular insert system
- Cell sourcesCell line– and iPSC-derived neural systems (application dependent)
- Plate format24-well, MEA-compatible
- Assay compatibilityImaging, biochemical assays, MEA
- Culture durationAcute to long-term
- Intended usersPharma, biotech, CROs, academic labs
Use this model in your research
The Brain MPS platform supports different study types depending on your team's resources, expertise, and timeline. Choose the approach that fits your workflow.
Build Your Own
Design a Custom Multi-Organ System with NANOSTACKS™
The NANOSTACKS™ Multi-Organ Builder lets you select one or multiple organs — Liver, Lung, Heart, Brain, Gut, Kidney, Skin — and automatically configures your multi-organ system with the right cell layers, compartments, and 3D visualisation.
- ✓Select organs individually or build a multi-organ panel
- ✓Cell layers and compartments configured automatically
- ✓Interactive 3D model updates in real time
- ✓Download schematic and request a quote in one step
