Multi-Organ Microphysiological System
Human-relevant multi-organ platform for studying organ–organ crosstalk and systemic toxicity
Integrate validated liver and brain models with controlled biochemical communication to investigate metabolism-driven, inflammatory, and secondary toxicities that single-organ assays cannot capture.
Multi-organ integration on the NANOSTACKS™ platform
The Multi-Organ MPS enables controlled physical separation of organ compartments while maintaining biochemical communication through media exchange.
Modular architecture with controlled biochemical communication.
Organ axes you can build
Select organ combinations based on your metabolic, inflammatory, or systemic biology questions. Each axis captures distinct organ–organ interactions relevant to toxicity assessment.
Liver–Brain Axis
For metabolism-driven neurotoxicity
Investigate hepatic bioactivation and downstream CNS effects. Liver generates metabolites; brain compartment assesses functional and structural neurotoxicity.
Key Capabilities
- Metabolite-driven toxicity
- CNS exposure effects
- Neural function assessment
Liver–Kidney Axis
For renal clearance and secondary nephrotoxicity
Study hepatic metabolism combined with renal handling and accumulation. Assess secondary kidney injury from metabolites or parent compound.
Key Capabilities
- Renal clearance
- Metabolite accumulation
- Secondary toxicity
Liver–Gut Axis
For intestinal metabolism and systemic exposure
Model first-pass metabolism and gut–liver signaling. Investigate how intestinal barrier and metabolism influence systemic exposure.
Key Capabilities
- First-pass metabolism
- Barrier function
- Inflammatory signaling
Custom Configurations
For specialized research objectives
Combine organ modules to match your research question. Contact us to discuss custom multi-organ configurations.
Key Capabilities
- Flexible assembly
- Scalable design
- Application-specific
Supported study capabilities
- Metabolism-driven and secondary organ toxicity
- Organ–organ crosstalk and mediated effects
- Systemic inflammatory responses
- Metabolite accumulation and renal handling
- Chronic and repeat-dose exposure models
- Mechanistic hypothesis testing beyond single-organ limitations
Readouts and data outputs
- Organ-specific functional biomarkers and viability assays
- Metabolite profiling and quantification
- Cytokine and inflammatory signaling
- Imaging-based structural and molecular readouts
- Electrophysiology (for neural compartments)
- AI-ready, structured multiparametric datasets
Validated performance
The multi-organ NANOSTACKS™ platform has been applied in validated studies investigating organ–organ interactions and systemic toxicity mechanisms.
Practical specifications
- Platform:NANOSTACKS™ modular MPS
- Plate format:24-well
- Flow mode:Static or dynamic
- Compatible organs:Liver and Brain MPS modules
- Modularity:Stackable, user-assembled configurations
- Assay compatibility:Biochemical, imaging, molecular, electrophysiology
Single-organ modules for multi-organ assembly
The Multi-Organ MPS integrates validated single-organ platforms. Explore the available modules you can combine.
Use this model in your research
The Multi-Organ MPS platform supports different study types depending on your team's resources, expertise, and timeline. Choose the approach that fits your workflow.
Build Your Own
Design a Custom Multi-Organ System with NANOSTACKS™
The NANOSTACKS™ Multi-Organ Builder lets you select one or multiple organs — Liver, Lung, Heart, Brain, Gut, Kidney, Skin — and automatically configures your multi-organ system with the right cell layers, compartments, and 3D visualisation.
- ✓Select organs individually or build a multi-organ panel
- ✓Cell layers and compartments configured automatically
- ✓Interactive 3D model updates in real time
- ✓Download schematic and request a quote in one step
Ready to add Multi-Organ MPS to your workflow?
Request a quote to configure the Multi-Organ MPS platform for your systemic toxicity studies.
View standard NANOSTACKS™ bundles →