Multiorgan toxicity testing
Why us
Our NANOSTACKSTM-based in vitro models recapitulate the cell-cell crosstalk and spatial cellular arrangement typical of the in vivo environment. This way, toxicity screening on our models can yield more in-vivo relevant results than the use of traditional models.
Liver-brain model: multiorgan toxicity
The model is built on 3 layers, using our proprietary technology NANOSTACKS™
- Layer 1: Liver component
- Cell type: differentiated HepaRG
- Differentiated HepaRG cells replicate functional characteristics of primary human hepatocytes such as CYP activity, and can therefore be used for metabolic and hepatotoxicity studies.
- Layer 2: Glial component
- Cell type: U-138 MG
- U-138 MG cells are an astrocytoma cell line used in the model to model a glial, astrocyte-like component.
- Layer 3: Neuronal component
- Cell type: SH-SY5Y
- Handling: each model can be moved or disassembled into independent NANOSTACK™ with the use of sterile forceps.
OUTPUTS
Contact us for alternative endpoints.
DATA
Application Note
Application Note: Modeling the Liver-Brain Axis with NANOSTACKS™
This comprehensive note encompasses the characterization of differentiated HepaRG cells on NANOSTACKS™, providing insights into their behaviour and functionality. Additionally, it outlines the execution of neurotoxicity testing, shedding light on how NANOSTACKSTM facilitates the study of intercellular interactions and potential cross-effects between liver and brain cells.
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If you're interested in discovering how our organ models can benefit your research, we invite you to get in touch with us. Our team is available to provide further insights and address any inquiries you may have.