Microphysiological Systems Platform

Human Biology Data for Better Drug Decisions

NANOSTACKS™ is a modular human microphysiological systems platform for predictive drug safety, efficacy, and multi-organ biology.

Predictive safety and efficacy data earlier in development
Model systemic biology across organs in a single platform
Decision-ready readouts designed for go/no-go confidence

Human-Relevant Evidence, Earlier in Development

Quantitative readouts designed to reveal mechanisms, transport, toxicity, and organ-to-organ effects before costly decisions.

79%

in vivo first-pass reduction replicated

26.8%

lower paclitaxel IC50 — liver-brain triculture vs monoculture

≥28 days

demonstrated culture duration on NANOSTACKS™

Up to 4

stackable biological compartments — 24-well format

Peer-Reviewed Science

Built on Peer-Reviewed Evidence

Featured Publication

A New Microphysiological Platform to Study the Permeation of Neuroactive Agents Across Intestinal and Brain Barriers

Biofabrication, 2026 · Peer-Reviewed

Pavan B., Botti G., Dalpiaz A., Sbordoni R., Talari A. & Llabjani V.

Validates NANOSTACKS™ as a robust in vitro tool for studying neuroactive drug transport across intestinal, blood-brain, and blood-CSF barriers.

Read Full Publication View All Resources

The Platform

From Single-Organ Models to Connected Human Biology

Modular organ models, physiological barriers, mechanistic readouts, and multi-organ interactions in one scalable platform.

Modular multi-organ systems and organ interactions
Integrated barrier modeling across physiological interfaces
Mechanistic readouts for decision-ready data

NANOSTACKS™ connected multi-barrier human biology diagram

Applications

Built for your research

High-impact applications across safety, efficacy, and complex biology.

Intestinal & Brain Barrier Modeling

Quantify drug permeation across barrier interfaces.

Replicate 79% in vivo first-pass reduction
BBB and BCSFB transport modeling
Quantitative PK/PD readouts

Liver Toxicity & Metabolism

Identify hepatotoxicity and metabolic risk early.

DILI risk prediction before clinical exposure
Metabolite-driven toxicity modeling
CYP-dependent drug interactions

Neurobiology & CNS Response

Measure functional responses in human systems.

Dopamine and neurotransmitter release
Seizure and electrophysiology detection
BBB penetration quantification

Multi-Organ Systems & Crosstalk

Capture systemic effects in one circuit.

Metabolite-driven cross-tissue interactions
Single fluidic compartment integration
Organ-to-organ communication

Workflow

From design to decision

Choose your model, run the study with us or in your lab, and turn human-relevant biology into decision-ready data.

Configure

Select organ systems, barrier models, and assay readouts.

Run Your Way

Send us your compounds for a fully managed study, or bring NANOSTACKS™ into your lab.

Analyze & Decide

Receive quantitative toxicity, PK/PD, and mechanistic readouts to support development decisions.

AI-driven molecular insight and safety prediction

Complementary Capability

AI-Assisted Safety & Design

Explainable AI identifies and interprets risk — then NANOSTACKS™ human data experimentally validates it.

01
Risk Detection
Identify structural and biological liabilities across DILI, neurotoxicity, and ADMET.
02
Mechanistic Understanding
Explain risk drivers with interpretable models — not black-box predictions.
03
Human Validation
Experimentally evaluate predictions in multi-organ human systems.

Bring Human Biology Earlier Into Your Pipeline

Generate predictive, mechanistic insight before costly decisions are made.