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Innovative Organ-on-a-Chip (OOAC) technology to improve research in human health and enhance drug discovery
Our mission is to empower scientists to conduct more creative and relevant research by providing next-generation cell culture technology that closely mimics in vivo conditions and reduces reliance on animal testing. Traditional culture plates and petri dishes are static and fail to replicate the complex nature of human cell-cell interactions. Conversely, current organ-on-a-chip technologies are complex, low-throughput, and costly.
Enter CELLBLOKS®, a patented, modular, plug-and-play organ-on-a-chip platform that emulates organ microenvironments in a standard in vitro setting. This multi-organ/cell type technology offers a simple and interactive solution for researchers to more accurately predict human responses to new drugs, cosmetics, foods, and viruses. With CELLBLOKS®, scientists can achieve a higher degree of physiological relevance and gain insights that were previously unattainable, enabling them to advance the field of human health research
A single platform allowing the study of cell-cell interactions in real-time
CELLBLOKS® 3D stack Liver-on-a-Chip model
Each plate of this model comprises 24 liver-chips, with each chip composed of layered scaffold blocks containing multiple liver cell types arranged in a 3D stacked format. These chips are primed for exposure to test drugs, with cells in close proximity for enhanced intercellular interactions and more physiologically relevant responses.
CELLBLOKS® 2D layout Liver-on-a-Chip model
The CELLBLOKS® kit includes liver micro-tissues that are grown adjacent to each other, comprising multiple cell types relevant to liver function. These micro-tissues are physiologically relevant and readily grown, enabling in vivo-like cell-cell interactions that are critical for predicting adverse drug effects in laboratory experiments. The metabolic function of the liver cells can be assessed using this model, providing an essential tool for accurately predicting drug reactions in vitro.
Use CELLBLOKS® kits to build your own unique organ models in your lab
CELLBLOKS® is a unique plate platform that enables the study of complex in vivo-like cell-cell interactions with unparalleled ease. This platform allows you to build complex models by simply assembling different cell growth blocks, which are designed to mimic both barrier organs and those in the systemic circulation. With CELLBLOKS®, you can easily create models that accurately reflect in vivo conditions, providing a valuable tool for studying cell behavior in various organs and tissues. No other platform offers the same level of versatility and ease of use as CELLBLOKS® when it comes to building complex in vitro models of physiological systems
"For biological research or drug discovery applications, striving towards organotypic structure and function will improve the translational relevance and predictivity of cell models. 3D assembly of multi-cellular structures, communication between cells within or across connected models alongside media flow are the focus of multiple organ on a chip (OOAC) technologies.
CELLBLOKS is a new entry into the OOAC space. It has plate-based familiarity with the potential to develop and connect multiple cell models exploiting the multi-modular nature of the technology. Established cell or trans-well based models can be migrated into the format and connected in multiple combinations with or without media flow. The approach exploits existing laboratory equipment and requires minimal training, enabling a lower barrier to investment and reduced model transition to the format compared to other approaches on the market."
"CELLBLOKS® is a true innovation for co-culture activities. The soluble factors including growth factors and cytokine can be smartly and conveniently introduced to targeted cellular population in a semi-quantitative manner. The working procedure is simple and easily implemented."
“CELLBLOKS® is great technology and innovative technique. Very easy to use and instructions are well designed. This platform enables us to screen various compounds in-vitro during our research using nanoparticles, aptamers, and others. We are interested to better mimic skin barrier and blood brain barrier and are continuing to explore the use of CELLBLOKS® for this purpose. Our research continues in this filed, to discover new products we would need models like CELLBLOKS® for testing permeation and penetration of cell lines. I would recommend it and encourage other researchers to use it.”
"CELLBLOKS® can be used to overcome the serious limitations hampering the use of organotypic slice cultures in long-term experiments. The system allows sharing of cell secreted factors released from three or more types of cross-communicating cells/tissues and can be easily adapted in studying cell-cell interactions in complex organs like the salivary glands."