CELLBLOKS® is an industry-compliant, high-throughput brain-on-a-chip platform specifically designed for studying drug toxicity and neurodevelopment effects. It enables the prediction of potential adverse effects in humans before clinical trials. The platform consists of 24 individual liver-chips per plate, each containing differentiated SH-SY5Y cells. These cells, known for their high reproducibility, accurately simulate neuronal behavior and facilitate the assessment of drug responses in the nervous system. With its optimized design, CELLBLOKS® ensures optimal functionality, user-friendliness, and compatibility with existing equipment, reducing both time and costs associated with research and development.

• SH-SY5Y cell culture: The Brain-on-a-Chip model utilizes differentiated SH-SY5Y cells, a human neuroblastoma cell line, providing a specific and focused neuronal model for studying drug effects on the nervous system.
• Ready to use: The chip model is pre-prepared and ready for immediate use upon arrival, saving time and allowing researchers to begin experiments promptly.
• Enhanced cellular functionality: Differentiated SH-SY5Y cells exhibit neuronal-like properties, including the ability to form synapses and express neuronal markers, enabling the study of neuronal development, drug responses, and neurotoxicity.
• Compatible with existing equipment: The Brain-on-a-Chip model is designed to seamlessly integrate with standard laboratory equipment, ensuring convenience and ease of use.
• Industry complient: Can fit into a standard SBS format well plate

• Improved predictive capabilities: By utilizing the SH-SY5Y cell-based Brain-on-a-Chip model, researchers can gain valuable insights into potential adverse effects of drugs on the nervous system before progressing to expensive and time-consuming clinical trials, leading to more accurate predictions and cost savings.
• Neurodevelopmental relevance: The differentiation process of SH-SY5Y cells mimics aspects of neuronal development, providing a relevant model for studying neurodevelopmental processes and identifying potential drug-induced effects on neuronal development.
• Pharmacological response assessment: Differentiated SH-SY5Y cells exhibit functional receptors and pathways that respond to various drugs and compounds. This enables researchers to assess drug efficacy, toxicity, and potential side effects on neuronal behavior and function.
• High reproducibility: SH-SY5Y cells are readily available and can be cultured in large quantities, ensuring consistent and reproducible results for drug screening experiments.
• Ethical considerations: Utilizing SH-SY5Y cells for drug screening reduces the need for animal models, contributing to the reduction and refinement of animal testing in pharmaceutical research.

• ASSAYS
•  Neurite Outgrowth Assay
• Immunohistochemistry
• Cell Viability Assays (ATP & MTT)
• RNA/DNA extraction
• Calcium Imaging Assay

• READ-OUTS
• Imaging (Phase-contrast, confocal and luminescence)
• Plate readers (Fluorescence intensity, absorbance, luminance)
• Downstream sampling of medium and cells (e.g., ELISA, PCR, biochemistry)
• Each cell layer can be removed and analysed separately without disturbing other layers